7EX6

Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Replicase	polymer	219	25181.9	4	UniProt (A0A059WLS9) Pfam (PF15518) In PDB	Abbey lake orthobunyavirus	Transcriptase,L protein
2	A, B, C, D	MANGANESE (II) ION	non-polymer		54.9	8	Chemie (MN)
3	A, B, C, D	methyl (Z)-4-(4-(4-chlorobenzyl)-1-(2-methylbenzyl)piperidin-4-yl)-2-hydroxy-4-oxobut-2-enoate	non-polymer		441.9	4	Chemie (11I)
4		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 183 (UniProt: A0A059WLS9)

PDB	External Database	Details
Met -35	-	initiating methionine
Gly -34	-	expression tag
Ser -33	-	expression tag
Ser -32	-	expression tag
His -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
Ser -25	-	expression tag
Ser -24	-	expression tag
Gly -23	-	expression tag
Leu -22	-	expression tag
Val -21	-	expression tag
Pro -20	-	expression tag
Arg -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
Met -15	-	expression tag
Ala -14	-	expression tag
Ser -13	-	expression tag
Met -12	-	expression tag
Thr -11	-	expression tag
Gly -10	-	expression tag
Gly -9	-	expression tag
Gln -8	-	expression tag
Gln -7	-	expression tag
Met -6	-	expression tag
Gly -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	100727.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2207.3
All*	Total formula weight	102934.8

*Water molecules are not included.