7EVU

Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with HFG and JE6

Summary for 7EVU

Entry DOI	10.2210/pdb7evu/pdb
Descriptor	Prolyl-tRNA synthetase (ProRS), 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide, ... (5 entities in total)
Functional Keywords	toxoplasma gondii, prolyl trna synthetase, inhibitor-bound structural comparison, translation, multi-drug
Biological source	Toxoplasma gondii
Total number of polymer chains	2
Total formula weight	117647.99
Authors	Mishra, S.,Malhotra, N.,Manickam, Y.,Sharma, A. (deposition date: 2021-05-22, release date: 2022-03-09, Last modification date: 2023-11-29)
Primary citation	Manickam, Y.,Malhotra, N.,Mishra, S.,Babbar, P.,Dusane, A.,Laleu, B.,Bellini, V.,Hakimi, M.A.,Bougdour, A.,Sharma, A. Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development. Plos Pathog., 18:e1010363-e1010363, 2022 Cited by PubMed: 35333915 DOI: 10.1371/journal.ppat.1010363 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.697 Å)

Structure validation