7EVU
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with HFG and JE6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue HFG A 901 |
| Chain | Residue |
| A | GLU418 |
| A | TRP589 |
| A | GLY590 |
| A | HOH1032 |
| A | HOH1045 |
| A | HOH1210 |
| A | VAL419 |
| A | PRO438 |
| A | THR439 |
| A | GLU441 |
| A | ARG470 |
| A | TRP487 |
| A | THR558 |
| A | HIS560 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue JE6 A 902 |
| Chain | Residue |
| A | GLU472 |
| A | LYS474 |
| A | GLN475 |
| A | PHE479 |
| A | LEU480 |
| A | ARG481 |
| A | THR482 |
| A | PHE485 |
| A | GLN555 |
| A | ALA556 |
| A | ALA557 |
| A | THR558 |
| A | GLY590 |
| A | THR592 |
| A | ARG594 |
| A | HOH1058 |
| A | HOH1100 |
| A | HOH1178 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue HFG B 901 |
| Chain | Residue |
| B | PRO417 |
| B | GLU418 |
| B | VAL419 |
| B | PRO438 |
| B | THR439 |
| B | GLU441 |
| B | ARG470 |
| B | TRP487 |
| B | HIS491 |
| B | THR558 |
| B | HIS560 |
| B | TRP589 |
| B | GLY590 |
| B | HOH1018 |
| B | HOH1070 |
| B | HOH1198 |
| B | HOH1210 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue JE6 B 902 |
| Chain | Residue |
| B | GLU472 |
| B | LYS474 |
| B | GLN475 |
| B | PHE479 |
| B | LEU480 |
| B | ARG481 |
| B | THR482 |
| B | PHE485 |
| B | GLN555 |
| B | ALA556 |
| B | ALA557 |
| B | THR558 |
| B | GLY590 |
| B | THR592 |
| B | ARG594 |
| B | HOH1085 |
| B | HOH1152 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MES B 903 |
| Chain | Residue |
| A | GLN379 |
| A | TRP465 |
| B | GLN379 |
| B | TRP465 |
| B | HOH1038 |
| B | HOH1112 |
| B | HOH1212 |
