7ENZ

Crystal structure of Phenanthredinone moiety in complex with the second bromodomain of BRD2 (BRD2-BD2).

Summary for 7ENZ

Entry DOI	10.2210/pdb7enz/pdb
Descriptor	Bromodomain-containing protein 2, phenanthridin-6(5H)-one, TRIETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13751.71
Authors	Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S. (deposition date: 2021-04-21, release date: 2022-03-09, Last modification date: 2023-11-29)
Primary citation	Arole, A.H.,Deshmukh, P.,Sridhar, A.,Padmanabhan, B. Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains. Acta Crystallogr.,Sect.F, 78:119-127, 2022 Cited by PubMed: 35234137 DOI: 10.1107/S2053230X22001066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation