7ENZ

Crystal structure of Phenanthredinone moiety in complex with the second bromodomain of BRD2 (BRD2-BD2).

7ENZ の概要

• エントリーDOI: 10.2210/pdb7enz/pdb
• 分子名称: Bromodomain-containing protein 2, phenanthridin-6(5H)-one, TRIETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13751.71

構造登録者

Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S. (登録日: 2021-04-21, 公開日: 2022-03-09, 最終更新日: 2023-11-29)

• 主引用文献: Arole, A.H.,Deshmukh, P.,Sridhar, A.,Padmanabhan, B.; Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains.; Acta Crystallogr.,Sect.F, 78:119-127, 2022; PubMed: 35234137; DOI: 10.1107/S2053230X22001066

実験手法

X-RAY DIFFRACTION (1.7 Å)