7EHN

Human MTHFD2 in complex with compound 21 and 9

Summary for 7EHN

Entry DOI	10.2210/pdb7ehn/pdb
Related	7EHJ 7EHM
Descriptor	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 3-[4-[[1-[(4-chloranyl-1H-indol-2-yl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]-6-methyl-pyrimidin-2-yl]propanoic acid, (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, ... (4 entities in total)
Functional Keywords	mthfd2, methylenetetrahydrofolate dehydrogenase 2, 1c metabolism, mitocondria, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	70249.72
Authors	Lee, L.C.,Peng, Y.H.,Wu, S.Y. (deposition date: 2021-03-30, release date: 2021-08-11, Last modification date: 2023-11-29)
Primary citation	Lee, L.C.,Peng, Y.H.,Chang, H.H.,Hsu, T.,Lu, C.T.,Huang, C.H.,Hsueh, C.C.,Kung, F.C.,Kuo, C.C.,Jiaang, W.T.,Wu, S.Y. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64:11288-11301, 2021 Cited by PubMed: 34337952 DOI: 10.1021/acs.jmedchem.1c00663 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation