7EF8

Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form I)

Summary for 7EF8

• Entry DOI: 10.2210/pdb7ef8/pdb
• Descriptor: Adenine DNA glycosylase, DNA (5'-D(*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3'), ... (7 entities in total)
• Functional Keywords: dna repair, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 60768.12

Authors

Nakamura, T.,Nakabeppu, Y.,Yamagata, Y. (deposition date: 2021-03-21, release date: 2021-06-23, Last modification date: 2023-11-29)

• Primary citation: Nakamura, T.,Okabe, K.,Hirayama, S.,Chirifu, M.,Ikemizu, S.,Morioka, H.,Nakabeppu, Y.,Yamagata, Y.; Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.; Nucleic Acids Res., 49:7154-7163, 2021; PubMed: 34142156; DOI: 10.1093/nar/gkab492

Experimental method

X-RAY DIFFRACTION (2.45 Å)