7EF8

Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form I)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006284	biological_process	base-excision repair
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019104	molecular_function	DNA N-glycosylase activity
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00764
Number of Residues	17
Details	ENDONUCLEASE_III_1 Endonuclease III iron-sulfur binding region signature. CtpqRPLCshCpvqslC

Chain	Residue	Details
A	CYS261-CYS277

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site_id	PS01155
Number of Residues	31
Details	ENDONUCLEASE_III_2 Endonuclease III family signature. GhMPrtaetLqqlLPGVGrytAgaiAsiAFD

Chain	Residue	Details
A	GLY170-ASP200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P83847

Chain	Residue	Details
A	GLU105

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS261
A	CYS268
A	CYS271
A	CYS277

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P83847

Chain	Residue	Details
A	ASP207

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