7EF8

Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form I)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006284	biological_process	base-excision repair
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019104	molecular_function	DNA N-glycosylase activity
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00764
Number of Residues	17
Details	ENDONUCLEASE_III_1 Endonuclease III iron-sulfur binding region signature. CtpqRPLCshCpvqslC

Chain	Residue	Details
A	CYS261-CYS277

---

site_id	PS01155
Number of Residues	31
Details	ENDONUCLEASE_III_2 Endonuclease III family signature. GhMPrtaetLqqlLPGVGrytAgaiAsiAFD

Chain	Residue	Details
A	GLY170-ASP200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	131
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	22
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P83847","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P83847","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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