7ECA

Crystal structure of the Keap1 complex with a peptide base on ETGE motif.

7ECA の概要

• エントリーDOI: 10.2210/pdb7eca/pdb
• 分子名称: Kelch-like ECH-associated protein 1, LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-LEU-PRO, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: nrf2, oxidative stress, cancer, cytosolic protein
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40821.12

構造登録者

Cheng, L.,Wang, C. (登録日: 2021-03-11, 公開日: 2022-03-16, 最終更新日: 2023-11-29)

主引用文献

Cheng, L.,Wang, H.,Li, S.,Liu, Z.,Wang, C.
New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.
Life Sci, 282:119791-119791, 2021

PubMed Abstract: Keap1-Nrf2 signaling pathway is one of the most important antioxidant signaling pathways, and its abnormal activation is related to cancer metastasis and drug resistance. Many studies have shown Keap1 and Nrf2 mutations are closely associated with cancer occurrence. However, few studies focus on Keap1-Nrf2 binding characteristics of cancer-associated mutations. The study investigated the molecular mechanism between Keap1/Nrf2 mutations and cancer.

PubMed: 34229009
DOI: 10.1016/j.lfs.2021.119791

実験手法

X-RAY DIFFRACTION (2.00006351943 Å)