7EAT
Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with compound 1
Summary for 7EAT
Entry DOI | 10.2210/pdb7eat/pdb |
Related | 7EA0 7EAS 7EBB 7EBG 7EBH |
Descriptor | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, SULFATE ION, 1,3-dihydro-2H-indol-2-one, ... (4 entities in total) |
Functional Keywords | pdhk, kinase inhibitors, fragment screening, pdk1, pdk2, pdk3, pdk4, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 91848.30 |
Authors | Orita, T.,Doi, S.,Iwanaga, T.,Adachi, T. (deposition date: 2021-03-08, release date: 2021-08-04, Last modification date: 2023-11-29) |
Primary citation | Akaki, T.,Bessho, Y.,Ito, T.,Fujioka, S.,Ubukata, M.,Mori, G.,Yamanaka, K.,Orita, T.,Doi, S.,Iwanaga, T.,Ikegashira, K.,Hantani, Y.,Nakanishi, I.,Adachi, T. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg.Med.Chem., 44:116283-116283, 2021 Cited by PubMed: 34274549DOI: 10.1016/j.bmc.2021.116283 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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