7EAT
Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | polymer | 404 | 45598.9 | 2 | UniProt (Q16654) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (Human) | Pyruvate dehydrogenase kinase isoform 4 |
| 2 | C, D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | E, H (A, B) | 1,3-dihydro-2H-indol-2-one | non-polymer | 133.1 | 2 | Chemie (W6P) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B: 10 - 411 (UniProt: Q16654)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Pro 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91197.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 650.5 | |
| All* | Total formula weight | 91848.3 |
