7E5H

HUMAN PPAR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH APHM6 OBTAINED BY COCRYSTALLIZATION

Summary for 7E5H

• Entry DOI: 10.2210/pdb7e5h/pdb
• Related: 2znn
• Descriptor: Peroxisome proliferator-activated receptor alpha, (2S)-2-[[3-[[3-fluoranyl-4-(4-fluoranylphenoxy)phenyl]methylcarbamoyl]-4-methoxy-phenyl]methyl]butanoic acid (3 entities in total)
• Functional Keywords: nuclear receptor, ppar, protein-ligand complex, transcription
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 31325.53

Authors

Oyama, T.,Kamata, S.,Ishii, I.,Miyachi, H. (deposition date: 2021-02-18, release date: 2021-10-06, Last modification date: 2023-11-29)

• Primary citation: Oyama, T.,Kamata, S.,Ishii, I.,Miyachi, H.; Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR) alpha Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method.; Biol.Pharm.Bull., 44:1202-1209, 2021; PubMed: 34471048; DOI: 10.1248/bpb.b21-00220

Experimental method

X-RAY DIFFRACTION (1.66 Å)