7DV4
Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4
Summary for 7DV4
Entry DOI | 10.2210/pdb7dv4/pdb |
Descriptor | Cytotoxic T-lymphocyte protein 4, 4003-1(VH), 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | anti-tumor, vh domain, complex, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 102367.85 |
Authors | |
Primary citation | Gan, X.,Shan, Q.,Li, H.,Janssens, R.,Shen, Y.,He, Y.,Chen, F.,van Haperen, R.,Drabek, D.,Li, J.,Zhang, Y.,Zhao, J.,Qin, B.,Jheng, M.J.,Chen, V.,Wang, J.,Rong, Y.,Grosveld, F. An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA, 119:e2200879119-e2200879119, 2022 Cited by PubMed: 35925889DOI: 10.1073/pnas.2200879119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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