7DV4

Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4

Summary for 7DV4

• Entry DOI: 10.2210/pdb7dv4/pdb
• Descriptor: Cytotoxic T-lymphocyte protein 4, 4003-1(VH), 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: anti-tumor, vh domain, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 102367.85

Authors

Li, H.,Gan, X.,He, Y. (deposition date: 2021-01-12, release date: 2022-01-12, Last modification date: 2023-11-29)

• Primary citation: Gan, X.,Shan, Q.,Li, H.,Janssens, R.,Shen, Y.,He, Y.,Chen, F.,van Haperen, R.,Drabek, D.,Li, J.,Zhang, Y.,Zhao, J.,Qin, B.,Jheng, M.J.,Chen, V.,Wang, J.,Rong, Y.,Grosveld, F.; An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile.; Proc.Natl.Acad.Sci.USA, 119:e2200879119-e2200879119, 2022; PubMed: 35925889; DOI: 10.1073/pnas.2200879119

Experimental method

X-RAY DIFFRACTION (2.38 Å)