7DPN
Crystal structure of BRD2(BD1)with ligand ZB-BD-224 bound
Summary for 7DPN
| Entry DOI | 10.2210/pdb7dpn/pdb |
| Descriptor | Bromodomain-containing protein 2, 5-(1-naphthoyl)-11-methyl-8-((methylsulfonyl)methyl)-4,5-dihydro-2,3a1,5-triazadibenzo[cd,h]azulen-1(2H)-one (3 entities in total) |
| Functional Keywords | antitumor; bet proteins; bromodomain inhibitor; epigenetic readers, antitumor protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 3 |
| Total formula weight | 44410.73 |
| Authors | |
| Primary citation | Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B. Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency To Be Published, |
| Experimental method | X-RAY DIFFRACTION (1.79998842375 Å) |
Structure validation
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