7DPN
Crystal structure of BRD2(BD1)with ligand ZB-BD-224 bound
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue HFU A 201 |
| Chain | Residue |
| A | TRP97 |
| A | HOH324 |
| B | GLN94 |
| A | PRO98 |
| A | VAL103 |
| A | LYS107 |
| A | LEU108 |
| A | LEU110 |
| A | ASN156 |
| A | ILE162 |
| A | HOH306 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue HFU B 201 |
| Chain | Residue |
| A | GLN94 |
| B | TRP97 |
| B | PRO98 |
| B | VAL103 |
| B | LYS107 |
| B | LEU108 |
| B | ASN156 |
| B | ILE162 |
| B | MET165 |
| B | HOH317 |
| B | HOH320 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
