7DN4

The crystal structure of Cpd8 in complex with BPTF bromodomain

7DN4 の概要

• エントリーDOI: 10.2210/pdb7dn4/pdb
• 分子名称: Nucleosome-remodeling factor subunit BPTF, 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-one (2 entities in total)
• 機能のキーワード: inhibitor, bptf, bromodomain, reader, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 88763.17

構造登録者

Xiong, L.,Guo, Y.,Yang, S. (登録日: 2020-12-08, 公開日: 2021-10-20, 最終更新日: 2023-11-29)

• 主引用文献: Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L.; Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.; Biochem.Biophys.Res.Commun., 545:125-131, 2021; PubMed: 33548625; DOI: 10.1016/j.bbrc.2021.01.067

実験手法

X-RAY DIFFRACTION (2.841 Å)