7DMC

Dipyridamole binds to the N-terminal domain of human Hsp90A

Summary for 7DMC

• Entry DOI: 10.2210/pdb7dmc/pdb
• Descriptor: Heat shock protein HSP 90-alpha, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: atp binding domain, hsp90, dipyridamole, chaperone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 24016.66

Authors

Shi, L.,Zhou, C.,Zhong, Y.,Gao, J.,Zhou, H.,Zhang, N. (deposition date: 2020-12-03, release date: 2021-12-08, Last modification date: 2023-11-29)

• Primary citation: Gao, J.,Zhou, C.,Zhong, Y.,Shi, L.,Luo, X.,Su, H.,Li, M.,Xu, Y.,Zhang, N.,Zhou, H.; Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines.; Biochem Pharmacol, 207:115376-115376, 2022; PubMed: 36513142; DOI: 10.1016/j.bcp.2022.115376

Experimental method

X-RAY DIFFRACTION (2.34 Å)