7DMC
Dipyridamole binds to the N-terminal domain of human Hsp90A
Summary for 7DMC
Entry DOI | 10.2210/pdb7dmc/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | atp binding domain, hsp90, dipyridamole, chaperone |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24016.66 |
Authors | |
Primary citation | Gao, J.,Zhou, C.,Zhong, Y.,Shi, L.,Luo, X.,Su, H.,Li, M.,Xu, Y.,Zhang, N.,Zhou, H. Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines. Biochem Pharmacol, 207:115376-115376, 2022 Cited by PubMed: 36513142DOI: 10.1016/j.bcp.2022.115376 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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