7D8B
Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
Summary for 7D8B
Entry DOI | 10.2210/pdb7d8b/pdb |
Descriptor | Eukaryotic translation initiation factor 4E, VH-S4 (3 entities in total) |
Functional Keywords | cap dependent translation, complex, vh domain, rna binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 84554.20 |
Authors | Frosi, Y.,Lin, Y.C.,Jiang, S.,Brown, C.J. (deposition date: 2020-10-07, release date: 2021-08-25, Last modification date: 2023-11-29) |
Primary citation | Frosi, Y.,Lin, Y.C.,Shimin, J.,Ramlan, S.R.,Hew, K.,Engman, A.H.,Pillai, A.,Yeung, K.,Cheng, Y.X.,Cornvik, T.,Nordlund, P.,Goh, M.,Lama, D.,Gates, Z.P.,Verma, C.S.,Thean, D.,Lane, D.P.,Asial, I.,Brown, C.J. Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex. Nat Commun, 13:4854-4854, 2022 Cited by PubMed: 35982046DOI: 10.1038/s41467-022-32463-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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