7D8B

Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000339	molecular_function	RNA cap binding
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000932	cellular_component	P-body
A	0001662	biological_process	behavioral fear response
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006406	biological_process	mRNA export from nucleus
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006417	biological_process	regulation of translation
A	0010494	cellular_component	cytoplasmic stress granule
A	0010507	biological_process	negative regulation of autophagy
A	0016281	cellular_component	eukaryotic translation initiation factor 4F complex
A	0016442	cellular_component	RISC complex
A	0016604	cellular_component	nuclear body
A	0016607	cellular_component	nuclear speck
A	0017148	biological_process	negative regulation of translation
A	0019827	biological_process	stem cell population maintenance
A	0019899	molecular_function	enzyme binding
A	0030182	biological_process	neuron differentiation
A	0031370	molecular_function	eukaryotic initiation factor 4G binding
A	0033391	cellular_component	chromatoid body
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0045665	biological_process	negative regulation of neuron differentiation
A	0045931	biological_process	positive regulation of mitotic cell cycle
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051028	biological_process	mRNA transport
A	0051168	biological_process	nuclear export
A	0070062	cellular_component	extracellular exosome
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0098794	cellular_component	postsynapse
A	0098808	molecular_function	mRNA cap binding
A	0098978	cellular_component	glutamatergic synapse
A	0099578	biological_process	regulation of translation at postsynapse, modulating synaptic transmission
A	0140297	molecular_function	DNA-binding transcription factor binding
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000339	molecular_function	RNA cap binding
C	0000340	molecular_function	RNA 7-methylguanosine cap binding
C	0000932	cellular_component	P-body
C	0001662	biological_process	behavioral fear response
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006406	biological_process	mRNA export from nucleus
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006417	biological_process	regulation of translation
C	0010494	cellular_component	cytoplasmic stress granule
C	0010507	biological_process	negative regulation of autophagy
C	0016281	cellular_component	eukaryotic translation initiation factor 4F complex
C	0016442	cellular_component	RISC complex
C	0016604	cellular_component	nuclear body
C	0016607	cellular_component	nuclear speck
C	0017148	biological_process	negative regulation of translation
C	0019827	biological_process	stem cell population maintenance
C	0019899	molecular_function	enzyme binding
C	0030182	biological_process	neuron differentiation
C	0031370	molecular_function	eukaryotic initiation factor 4G binding
C	0033391	cellular_component	chromatoid body
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0045665	biological_process	negative regulation of neuron differentiation
C	0045931	biological_process	positive regulation of mitotic cell cycle
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051028	biological_process	mRNA transport
C	0051168	biological_process	nuclear export
C	0070062	cellular_component	extracellular exosome
C	0071549	biological_process	cellular response to dexamethasone stimulus
C	0098794	cellular_component	postsynapse
C	0098808	molecular_function	mRNA cap binding
C	0098978	cellular_component	glutamatergic synapse
C	0099578	biological_process	regulation of translation at postsynapse, modulating synaptic transmission
C	0140297	molecular_function	DNA-binding transcription factor binding

Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW

Chain	Residue	Details
A	ASP90-TRP113

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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