7CWF
Crystal structure of PDE8A catalytic domain in complex with 2c
Summary for 7CWF
Entry DOI | 10.2210/pdb7cwf/pdb |
Descriptor | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | camp-specific, hydrolase, selective pde8a inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39520.45 |
Authors | Huang, Y.,Wu, X.-N.,Zhou, Q.,Wu, Y.,Luo, H.-B. (deposition date: 2020-08-28, release date: 2021-09-01, Last modification date: 2023-11-29) |
Primary citation | Huang, Y.,Wu, X.N.,Zhou, Q.,Wu, Y.,Zheng, D.,Li, Z.,Guo, L.,Luo, H.B. Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63:15852-15863, 2020 Cited by PubMed: 33291877DOI: 10.1021/acs.jmedchem.0c01573 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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