7CTY

Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS), fragment 263, NADP+, dUMP

Summary for 7CTY

• Entry DOI: 10.2210/pdb7cty/pdb
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, spiro[1H-2-benzofuran-3,4'-piperidine], ... (5 entities in total)
• Functional Keywords: dihydrofolate reductase, plasmodium falciparum, antimalarial, antifolate, fragment, antibiotic, oxidoreductase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 2
• Total formula weight: 144969.87

Authors

Vanichtanankul, J.,Vitsupakorn, D. (deposition date: 2020-08-20, release date: 2021-03-31, Last modification date: 2023-11-29)

• Primary citation: Hoarau, M.,Vanichtanankul, J.,Srimongkolpithak, N.,Vitsupakorn, D.,Yuthavong, Y.,Kamchonwongpaisan, S.; Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening.; J Enzyme Inhib Med Chem, 36:198-206, 2021; PubMed: 33530764; DOI: 10.1080/14756366.2020.1854244

Experimental method

X-RAY DIFFRACTION (2.8 Å)