7CP1

Crystal structure of isocitrate lyase in complex with succinate and itaconate

Summary for 7CP1

• Entry DOI: 10.2210/pdb7cp1/pdb
• Descriptor: Isocitrate lyase, SUCCINIC ACID, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: glyoxylate cycle, isocitrate lyase, succinate, itaconate, mycobacterium tuberculosis, lyase
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 2
• Total formula weight: 96707.86

Authors

Kwon, S.,Park, H.H. (deposition date: 2020-08-05, release date: 2021-05-19, Last modification date: 2023-11-29)

• Primary citation: Kwon, S.,Chun, H.L.,Ha, H.J.,Lee, S.Y.,Park, H.H.; Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism.; Plos One, 16:e0251067-e0251067, 2021; PubMed: 33951112; DOI: 10.1371/journal.pone.0251067

Experimental method

X-RAY DIFFRACTION (2.58 Å)