7CP1
Crystal structure of isocitrate lyase in complex with succinate and itaconate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isocitrate lyase | polymer | 436 | 48205.5 | 2 | UniProt (P9WKK7) Pfam (PF00463) | Mycobacterium tuberculosis H37Rv | ICL,Isocitrase,Isocitratase |
| 2 | C (A) | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (B) | 2-methylidenebutanedioic acid | non-polymer | 130.1 | 1 | Chemie (ITN) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 631 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 428 (UniProt: P9WKK7)
| PDB | External Database | Details |
|---|---|---|
| Leu 429 | - | expression tag |
| Glu 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96411.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 296.8 | |
| All* | Total formula weight | 96707.9 |
