7CP1

Crystal structure of isocitrate lyase in complex with succinate and itaconate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Isocitrate lyase	polymer	436	48205.5	2	UniProt (P9WKK7) Pfam (PF00463) In PDB	Mycobacterium tuberculosis H37Rv	ICL,Isocitrase,Isocitratase
2	A	SUCCINIC ACID	non-polymer		118.1	1	Chemie (SIN)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	B	2-methylidenebutanedioic acid	non-polymer		130.1	1	Chemie (ITN)
5		water	water		18.0	631	Chemie (HOH)

Sequence modifications

A, B: 1 - 428 (UniProt: P9WKK7)

PDB	External Database	Details
Leu 429	-	expression tag
Glu 430	-	expression tag
His 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96411.1
Non-Polymers*	Number of molecules	4
	Total formula weight	296.8
All*	Total formula weight	96707.9

*Water molecules are not included.