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7CNM

YDX in complex with tubulin

Summary for 7CNM
Entry DOI10.2210/pdb7cnm/pdb
DescriptorTubulin alpha-1B chain, (2~{S},4~{S})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-4-methyl-3-[[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-cyclohexyl-2-methyl-pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywordsydx, tubulin, protein-drug complex, cell cycle
Biological sourceMus musculus (Mouse)
More
Total number of polymer chains6
Total formula weight266248.02
Authors
Wang, Y.X.,Wu, C.Y. (deposition date: 2020-08-02, release date: 2021-08-04, Last modification date: 2023-11-29)
Primary citationChengyong, W.,Jinghong, X.,Yanyan, W.,Qing-Jie, X.,Lingling, M.,Yuyan, L.,Hai, C.,Qian, L.,Quan, Z.,Bo, S.,Yuxi, W.
The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.
Febs Lett., 595:195-205, 2021
Cited by
PubMed: 33220079
DOI: 10.1002/1873-3468.14003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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