7CNL

Crystal structure of TEAD3 in complex with VT105

Summary for 7CNL

Entry DOI	10.2210/pdb7cnl/pdb
Descriptor	Transcriptional enhancer factor TEF-5, N-oxidanyltetradecanamide, PHOSPHATE ION, ... (7 entities in total)
Functional Keywords	tead, inhibitor, palmitoylation, hippo pathway, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	103816.69
Authors	Tang, T.T.,Konradi, A.W. (deposition date: 2020-08-01, release date: 2021-04-28, Last modification date: 2023-11-29)
Primary citation	Tang, T.T.,Konradi, A.W.,Feng, Y.,Peng, X.,Ma, M.,Li, J.,Yu, F.X.,Guan, K.L.,Post, L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2 -deficient Mesothelioma. Mol.Cancer Ther., 20:986-998, 2021 Cited by PubMed: 33850002 DOI: 10.1158/1535-7163.MCT-20-0717 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation