7CMZ

Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8

7CMZ の概要

• エントリーDOI: 10.2210/pdb7cmz/pdb
• 分子名称: DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: topbp1, protein binding-hydrolase complex, protein binding/hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28544.43

構造登録者

Che, S.Y.,Ma, S.,Cao, C.,Yao, Z.,Shi, L.,Yang, N. (登録日: 2020-07-29, 公開日: 2021-03-17, 最終更新日: 2023-11-29)

• 主引用文献: Ma, S.,Cao, C.,Che, S.,Wang, Y.,Su, D.,Liu, S.,Gong, W.,Liu, L.,Sun, J.,Zhao, J.,Wang, Q.,Song, N.,Ge, T.,Guo, Q.,Tian, S.,Chen, C.D.,Zhang, T.,Wang, J.,Ding, X.,Yang, F.,Ying, G.,Yang, J.,Zhang, K.,Zhu, Y.,Yao, Z.,Yang, N.,Shi, L.; PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.; Sci Adv, 7:-, 2021; PubMed: 33952527; DOI: 10.1126/sciadv.abf7684

実験手法

X-RAY DIFFRACTION (1.695 Å)