7CMM

Crystal structure of TEAD1-YBD in complex with K-975

7CMM の概要

• エントリーDOI: 10.2210/pdb7cmm/pdb
• 分子名称: Transcriptional enhancer factor TEF-1, N-[3-(4-chloranylphenoxy)-4-methyl-phenyl]propanamide (3 entities in total)
• 機能のキーワード: transcriptional enhancer factor tef-1, tead, tead1, yap binding domain, ybd, inhibitor, covalent binder, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 107439.68

構造登録者

Tsuji, Y.,Suzuki, M.,Yasunaga, M.,Hamguchi, K.,Saito, J. (登録日: 2020-07-28, 公開日: 2021-02-03, 最終更新日: 2023-11-29)

• 主引用文献: Kaneda, A.,Seike, T.,Danjo, T.,Nakajima, T.,Otsubo, N.,Yamaguchi, D.,Tsuji, Y.,Hamaguchi, K.,Yasunaga, M.,Nishiya, Y.,Suzuki, M.,Saito, J.I.,Yatsunami, R.,Nakamura, S.,Sekido, Y.,Mori, K.; The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.; Am J Cancer Res, 10:4399-4415, 2020; PubMed: 33415007

実験手法

X-RAY DIFFRACTION (3.5 Å)