7CM0

Crystal structure of a glutaminyl cyclase in complex with NHV-1009

7CM0 の概要

• エントリーDOI: 10.2210/pdb7cm0/pdb
• 分子名称: Glutaminyl-peptide cyclotransferase, 1-(cyclopentylmethyl)-1-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]urea, ZINC ION, ... (4 entities in total)
• 機能のキーワード: glutaminyl cyclases (qcs), alzheimer disease, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151857.19

構造登録者

Lee, J.W.,Song, J.Y.,Jang, T.H.,Ha, J.H. (登録日: 2020-07-23, 公開日: 2021-12-22, 最終更新日: 2023-11-29)

• 主引用文献: Van Manh, N.,Hoang, V.H.,Ngo, V.T.H.,Ann, J.,Jang, T.H.,Ha, J.H.,Song, J.Y.,Ha, H.J.,Kim, H.,Kim, Y.H.,Lee, J.,Lee, J.; Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.; Eur.J.Med.Chem., 226:113819-113819, 2021; PubMed: 34536669; DOI: 10.1016/j.ejmech.2021.113819

実験手法

X-RAY DIFFRACTION (2.2 Å)