7CKK
Structural complex of FTO bound with Dac51
Summary for 7CKK
Entry DOI | 10.2210/pdb7ckk/pdb |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE, 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, demethylase, rna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 54916.63 |
Authors | |
Primary citation | Liu, Y.,Liang, G.,Xu, H.,Dong, W.,Dong, Z.,Qiu, Z.,Zhang, Z.,Li, F.,Huang, Y.,Li, Y.,Wu, J.,Yin, S.,Zhang, Y.,Guo, P.,Liu, J.,Xi, J.J.,Jiang, P.,Han, D.,Yang, C.G.,Xu, M.M. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33:1221-1233.e11, 2021 Cited by PubMed: 33910046DOI: 10.1016/j.cmet.2021.04.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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