7CKK

Structural complex of FTO bound with Dac51

7CKK の概要

• エントリーDOI: 10.2210/pdb7ckk/pdb
• 分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE, 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, demethylase, rna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54916.63

構造登録者

Yang, C.,Gan, J. (登録日: 2020-07-17, 公開日: 2021-07-21, 最終更新日: 2023-11-29)

• 主引用文献: Liu, Y.,Liang, G.,Xu, H.,Dong, W.,Dong, Z.,Qiu, Z.,Zhang, Z.,Li, F.,Huang, Y.,Li, Y.,Wu, J.,Yin, S.,Zhang, Y.,Guo, P.,Liu, J.,Xi, J.J.,Jiang, P.,Han, D.,Yang, C.G.,Xu, M.M.; Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.; Cell Metab., 33:1221-1233.e11, 2021; PubMed: 33910046; DOI: 10.1016/j.cmet.2021.04.001

実験手法

X-RAY DIFFRACTION (2.35 Å)