7CFO

Crystal structure of human RXRalpha ligand binding domain complexed with CBTF-EE.

7CFO の概要

• エントリーDOI: 10.2210/pdb7cfo/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, 1-[3-(2-ethoxyethoxy)-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl]-2-(trifluoromethyl)benzimidazole-5-carboxylic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: retinoid x receptor alpha, antagonist, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 110194.98

構造登録者

Watanabe, M.,Fujihara, M.,Motoyama, T.,Kawasaki, M.,Yamada, S.,Takamura, Y.,Ito, S.,Makishima, M.,Nakano, S.,Kakuta, H. (登録日: 2020-06-27, 公開日: 2021-01-06, 最終更新日: 2023-11-29)

• 主引用文献: Watanabe, M.,Fujihara, M.,Motoyama, T.,Kawasaki, M.,Yamada, S.,Takamura, Y.,Ito, S.,Makishima, M.,Nakano, S.,Kakuta, H.; Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers.; J.Med.Chem., 64:430-439, 2021; PubMed: 33356247; DOI: 10.1021/acs.jmedchem.0c01354

実験手法

X-RAY DIFFRACTION (2.15 Å)