7CET

Crystal structure of D-cycloserine-bound form of cysteine desulfurase NifS from Helicobacter pylori

Summary for 7CET

Entry DOI	10.2210/pdb7cet/pdb
Descriptor	Cysteine desulfurase IscS, ISOPROPYL ALCOHOL, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	cysteine desulfurase, plp-dependent enzyme, cysteine metabolism, cycloserine, inhibitor, fe-s cluster biosynthesis, biosynthetic protein
Biological source	Helicobacter pylori 26695
Total number of polymer chains	1
Total formula weight	44552.00
Authors	Nakamura, R.,Takahashi, Y.,Fujishiro, T. (deposition date: 2020-06-24, release date: 2021-06-30, Last modification date: 2023-11-29)
Primary citation	Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J., 2022 Cited by PubMed: 35395703 DOI: 10.1111/febs.16455 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation