7CD0
Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human hydroxymethylbilane synthase
Summary for 7CD0
Entry DOI | 10.2210/pdb7cd0/pdb |
Descriptor | Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid, ... (4 entities in total) |
Functional Keywords | porphyrin synthesis, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 80795.77 |
Authors | Sato, H.,Sugishima, M.,Wada, K.,Hirabayashi, K.,Tsukaguchi, M. (deposition date: 2020-06-18, release date: 2021-03-17, Last modification date: 2023-11-29) |
Primary citation | Sato, H.,Sugishima, M.,Tsukaguchi, M.,Masuko, T.,Iijima, M.,Takano, M.,Omata, Y.,Hirabayashi, K.,Wada, K.,Hisaeda, Y.,Yamamoto, K. Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps. Biochem.J., 478:1023-1042, 2021 Cited by PubMed: 33600566DOI: 10.1042/BCJ20200996 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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