7CA3

Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator rac-BHFF

Summary for 7CA3

• Entry DOI: 10.2210/pdb7ca3/pdb
• EMDB information: 30323
• Descriptor: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, CHOLESTEROL, ... (4 entities in total)
• Functional Keywords: gpcr, gaba, neurosignalling, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 180969.76

Authors

Kim, Y.,Jeong, E.,Jeong, J.,Kim, Y.,Cho, Y. (deposition date: 2020-06-08, release date: 2020-11-11)

• Primary citation: Kim, Y.,Jeong, E.,Jeong, J.H.,Kim, Y.,Cho, Y.; Structural Basis for Activation of the Heterodimeric GABA B Receptor.; J.Mol.Biol., 432:5966-5984, 2020; PubMed: 33058878; DOI: 10.1016/j.jmb.2020.09.023

Experimental method

ELECTRON MICROSCOPY (4.5 Å)