7CA3
Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator rac-BHFF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gamma-aminobutyric acid type B receptor subunit 1 | polymer | 771 | 87248.2 | 1 | UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003) | Homo sapiens (Human) | Gb1 |
| 2 | B (B) | Gamma-aminobutyric acid type B receptor subunit 2 | polymer | 822 | 92231.3 | 1 | UniProt (O75899) Pfam (PF01094) Pfam (PF00003) | Homo sapiens (Human) | Gb2,G-protein coupled receptor 51,HG20 |
| 3 | C, D, E (A, B) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 4 | F (B) | (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one | non-polymer | 330.3 | 1 | Chemie (FN0) PubChem (4332683) PubChem (7023847) PubChem (7023848) |
Sequence modifications
A: 165 - 900 (UniProt: Q9UBS5)
B: 1 - 787 (UniProt: O75899)
| PDB | External Database | Details |
|---|---|---|
| Met 139 | - | initiating methionine |
| Arg 140 | - | expression tag |
| Leu 141 | - | expression tag |
| Leu 142 | - | expression tag |
| Thr 143 | - | expression tag |
| Ala 144 | - | expression tag |
| Leu 145 | - | expression tag |
| Phe 146 | - | expression tag |
| Ala 147 | - | expression tag |
| Tyr 148 | - | expression tag |
| Phe 149 | - | expression tag |
| Ile 150 | - | expression tag |
| Val 151 | - | expression tag |
| Ala 152 | - | expression tag |
| Leu 153 | - | expression tag |
| Ile 154 | - | expression tag |
| Leu 155 | - | expression tag |
| Ala 156 | - | expression tag |
| Phe 157 | - | expression tag |
| Ser 158 | - | expression tag |
| Val 159 | - | expression tag |
| Ser 160 | - | expression tag |
| Ala 161 | - | expression tag |
| Lys 162 | - | expression tag |
| Ser 163 | - | expression tag |
| Met 164 | - | expression tag |
| Ser 901 | - | expression tag |
| Gly 902 | - | expression tag |
| Arg 903 | - | expression tag |
| Leu 904 | - | expression tag |
| Glu 905 | - | expression tag |
| Val 906 | - | expression tag |
| Leu 907 | - | expression tag |
| Phe 908 | - | expression tag |
| Gln 909 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 788 | - | expression tag |
| Gly 789 | - | expression tag |
| Arg 790 | - | expression tag |
| Gly 791 | - | expression tag |
| Gly 792 | - | expression tag |
| Ser 793 | - | expression tag |
| Glu 794 | - | expression tag |
| Asn 795 | - | expression tag |
| Leu 796 | - | expression tag |
| Tyr 797 | - | expression tag |
| Phe 798 | - | expression tag |
| Gln 799 | - | expression tag |
| Gly 800 | - | expression tag |
| Gly 801 | - | expression tag |
| Ser 802 | - | expression tag |
| Gly 803 | - | expression tag |
| Ser 804 | - | expression tag |
| Gly 805 | - | expression tag |
| Gly 806 | - | expression tag |
| Asp 807 | - | expression tag |
| Tyr 808 | - | expression tag |
| Lys 809 | - | expression tag |
| Asp 810 | - | expression tag |
| Asp 811 | - | expression tag |
| Asp 812 | - | expression tag |
| Asp 813 | - | expression tag |
| Lys 814 | - | expression tag |
| Asp 815 | - | expression tag |
| Tyr 816 | - | expression tag |
| Lys 817 | - | expression tag |
| Asp 818 | - | expression tag |
| Asp 819 | - | expression tag |
| Asp 820 | - | expression tag |
| Asp 821 | - | expression tag |
| Lys 822 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 179479.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1490.3 | |
| All* | Total formula weight | 180969.8 |
