7C6B

Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate

Summary for 7C6B

• Entry DOI: 10.2210/pdb7c6b/pdb
• Related: 6L45
• Descriptor: Protein argonaute-2, 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: argonaute, mid domain, ribonucleoprotein, rna-binding, rna-mediated gene silencing, translation regulation, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 48026.62

Authors

Suzuki, M.,Takahashi, Y.,Saito, J.,Miyagi, H.,Shinohara, F. (deposition date: 2020-05-21, release date: 2020-11-25, Last modification date: 2023-11-29)

• Primary citation: Shinohara, F.,Oashi, T.,Harumoto, T.,Nishikawa, T.,Takayama, Y.,Miyagi, H.,Takahashi, Y.,Nakajima, T.,Sawada, T.,Koda, Y.,Makino, A.,Sato, A.,Hamaguchi, K.,Suzuki, M.,Yamamoto, J.,Tomari, Y.,Saito, J.I.; siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.; Rna, 27:163-173, 2021; PubMed: 33177188; DOI: 10.1261/rna.073783.119

Experimental method

X-RAY DIFFRACTION (1.7 Å)