7C60

Crystal structure of Keap1 in complex with monoethyl fumarate (MEF)

Summary for 7C60

• Entry DOI: 10.2210/pdb7c60/pdb
• Related: 6LRZ
• Descriptor: Kelch-like ECH-associated protein 1, (~{Z})-4-ethoxy-4-oxidanylidene-but-2-enoic acid, ACETATE ION, ... (5 entities in total)
• Functional Keywords: beta-propeller domain, oxidative stress, keap1-nrf2 system, dmf, inhibitor complex, cytosolic protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 34652.53

Authors

Padmanabhan, B.,Unni, S.,Deshmukh, P.,Krishnappa, G. (deposition date: 2020-05-21, release date: 2020-08-05, Last modification date: 2023-11-29)

• Primary citation: Unni, S.,Deshmukh, P.,Krishnappa, G.,Kommu, P.,Padmanabhan, B.; Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.; Febs J., 288:1599-1613, 2021; PubMed: 32672401; DOI: 10.1111/febs.15485

Experimental method

X-RAY DIFFRACTION (1.95 Å)