7C60
Crystal structure of Keap1 in complex with monoethyl fumarate (MEF)
Summary for 7C60
Entry DOI | 10.2210/pdb7c60/pdb |
Related | 6LRZ |
Descriptor | Kelch-like ECH-associated protein 1, (~{Z})-4-ethoxy-4-oxidanylidene-but-2-enoic acid, ACETATE ION, ... (5 entities in total) |
Functional Keywords | beta-propeller domain, oxidative stress, keap1-nrf2 system, dmf, inhibitor complex, cytosolic protein |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 34652.53 |
Authors | Padmanabhan, B.,Unni, S.,Deshmukh, P.,Krishnappa, G. (deposition date: 2020-05-21, release date: 2020-08-05, Last modification date: 2023-11-29) |
Primary citation | Unni, S.,Deshmukh, P.,Krishnappa, G.,Kommu, P.,Padmanabhan, B. Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. Febs J., 288:1599-1613, 2021 Cited by PubMed: 32672401DOI: 10.1111/febs.15485 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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