7C44

Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a

Summary for 7C44

• Entry DOI: 10.2210/pdb7c44/pdb
• Descriptor: Protein Mdm4, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... (4 entities in total)
• Functional Keywords: mdmx, nutlin-3a, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 11888.59

Authors

Cheng, X.Y.,Zhang, B.L.,Kuang, Z.K.,Yang, J.,Li, Z.C.,Yu, J.P.,Zhao, Z.T.,Cao, C.Z.,Su, Z.D. (deposition date: 2020-05-15, release date: 2020-06-17, Last modification date: 2023-11-29)

• Primary citation: Cheng, X.Y.,Zhang, B.L.,Kuang, Z.K.,Yang, J.,Li, Z.C.,Yu, J.P.,Zhao, Z.T.,Cao, C.Z.,Su, Z.D.; Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)