7BVE
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol
Summary for 7BVE
Entry DOI | 10.2210/pdb7bve/pdb |
EMDB information | 30217 |
Descriptor | Integral membrane indolylacetylinositol arabinosyltransferase EmbC, Meromycolate extension acyl carrier protein, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | mycobacterium smegmatis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, embc, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, transferase |
Biological source | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) More |
Total number of polymer chains | 4 |
Total formula weight | 256640.96 |
Authors | |
Primary citation | Zhang, L.,Zhao, Y.,Gao, Y.,Wu, L.,Gao, R.,Zhang, Q.,Wang, Y.,Wu, C.,Wu, F.,Gurcha, S.S.,Veerapen, N.,Batt, S.M.,Zhao, W.,Qin, L.,Yang, X.,Wang, M.,Zhu, Y.,Zhang, B.,Bi, L.,Zhang, X.,Yang, H.,Guddat, L.W.,Xu, W.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z. Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Science, 368:1211-1219, 2020 Cited by PubMed: 32327601DOI: 10.1126/science.aba9102 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.81 Å) |
Structure validation
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