7BV5

Crystal structure of the yeast heterodimeric ADAT2/3

Summary for 7BV5

• Entry DOI: 10.2210/pdb7bv5/pdb
• Descriptor: tRNA-specific adenosine deaminase subunit TAD2, tRNA-specific adenosine deaminase subunit TAD3, ZINC ION, ... (4 entities in total)
• Functional Keywords: deaminase, inosine, auto-inhibition, rna binding protein, rna modification, hydrolase
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 4
• Total formula weight: 132917.21

Authors

Xie, W.,Liu, X.,Chen, R.,Sun, Y.,Chen, R.,Zhou, J.,Tian, Q. (deposition date: 2020-04-09, release date: 2020-11-18, Last modification date: 2023-11-29)

Primary citation

Liu, X.,Chen, R.,Sun, Y.,Chen, R.,Zhou, J.,Tian, Q.,Tao, X.,Zhang, Z.,Luo, G.Z.,Xie, W.
Crystal structure of the yeast heterodimeric ADAT2/3 deaminase.
Bmc Biol., 18:189-189, 2020

PubMed Abstract: The adenosine-to-inosine (A-to-I) editing in anticodons of tRNAs is critical for wobble base-pairing during translation. This modification is produced via deamination on A34 and catalyzed by the adenosine deaminase acting on tRNA (ADAT) enzyme. Eukaryotic ADATs are heterodimers composed of the catalytic subunit ADAT2 and the structural subunit ADAT3, but their molecular assemblies and catalytic mechanisms are largely unclear.

PubMed: 33272269
DOI: 10.1186/s12915-020-00920-2

Experimental method

X-RAY DIFFRACTION (2.8 Å)