7BV2

The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)

Summary for 7BV2

• Entry DOI: 10.2210/pdb7bv2/pdb
• EMDB information: 30210
• Descriptor: RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (10 entities in total)
• Functional Keywords: sars-cov-2, rna polymerase, remdesivir, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 5
• Total formula weight: 159190.94

Authors

Yin, W.,Mao, C.,Luan, X.,Shen, D.,Shen, Q.,Su, H.,Wang, X.,Zhou, F.,Zhao, W.,Gao, M.,Chang, S.,Xie, Y.C.,Tian, G.,Jiang, H.W.,Tao, S.C.,Shen, J.,Jiang, Y.,Jiang, H.,Xu, Y.,Zhang, S.,Zhang, Y.,Xu, H.E. (deposition date: 2020-04-09, release date: 2020-04-22, Last modification date: 2024-03-27)

• Primary citation: Yin, W.,Mao, C.,Luan, X.,Shen, D.D.,Shen, Q.,Su, H.,Wang, X.,Zhou, F.,Zhao, W.,Gao, M.,Chang, S.,Xie, Y.C.,Tian, G.,Jiang, H.W.,Tao, S.C.,Shen, J.,Jiang, Y.,Jiang, H.,Xu, Y.,Zhang, S.,Zhang, Y.,Xu, H.E.; Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.; Science, 368:1499-1504, 2020; PubMed: 32358203; DOI: 10.1126/science.abc1560

Experimental method

ELECTRON MICROSCOPY (2.5 Å)