7BV2

The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016740	molecular_function	transferase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS295
A	CYS301
A	CYS306
A	CYS310

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS487
A	HIS642
A	CYS645
A	CYS646

---

site_id	AC3
Number of Residues	4
Details	binding site for residue POP A 1003

Chain	Residue
A	ASP623
A	MG1004
P	F86101
A	ARG553

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 1004

Chain	Residue
A	TYR619
A	ASP760
A	POP1003
P	F86101

---

site_id	AC5
Number of Residues	2
Details	binding site for residue MG A 1005

Chain	Residue
A	ASP761
P	U20

---

site_id	AC6
Number of Residues	11
Details	binding site for residue F86 P 101

Chain	Residue
A	ARG555
A	ASP623
A	SER682
A	THR687
A	ASN691
A	ASP760
A	POP1003
A	MG1004
P	U20
T	U10
T	A11

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM

Chain	Residue	Details
A	GLY590-MET601

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
C	MET0
C	GLN83
A	ASP761

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ

Chain	Residue	Details
A	ASN209
A	ASP218

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01344, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ

Chain	Residue	Details
A	HIS295
A	CYS301
A	CYS306
A	CYS310

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ

Chain	Residue	Details
A	CYS487
A	HIS642
A	CYS646

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691

Chain	Residue	Details
A	CYS645

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
A	MET0
A	GLN932

---