7BV2

The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-directed RNA polymerase	polymer	951	109070.4	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	pp1ab,ORF1ab polyprotein,Pol,RdRp,Non-structural protein 12,nsp12
2	B	Non-structural protein 8	polymer	207	23139.4	1	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	pp1ab,ORF1ab polyprotein,nsp8
3	C	Non-structural protein 7	polymer	92	10485.2	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	pp1ab,ORF1ab polyprotein,nsp7
4	P	Primer	polymer	20	6410.8	1		Severe acute respiratory syndrome coronavirus 2
5	T	Templete	polymer	30	9358.5	1		Severe acute respiratory syndrome coronavirus 2
6	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	A	PYROPHOSPHATE 2-	non-polymer		176.0	1	Chemie (POP)
8	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
9	P	[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate	non-polymer		371.2	1	Chemie (F86)
10		water	water		18.0	5	Chemie (HOH)

Sequence modifications

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 933	-	expression tag
Gly 934	-	expression tag
Ser 935	-	expression tag
Glu 936	-	expression tag
Asn 937	-	expression tag
Leu 938	-	expression tag
Tyr 939	-	expression tag
Phe 940	-	expression tag
Gln 941	-	expression tag
Gly 942	-	expression tag
His 943	-	expression tag
His 944	-	expression tag
His 945	-	expression tag
His 946	-	expression tag
His 947	-	expression tag
His 948	-	expression tag
His 949	-	expression tag
His 950	-	expression tag

B: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
His 84	-	expression tag
His 85	-	expression tag
His 86	-	expression tag
His 87	-	expression tag
His 88	-	expression tag
His 89	-	expression tag
His 90	-	expression tag
His 91	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	158464.3
Non-Polymers*	Number of molecules	6
	Total formula weight	726.6
All*	Total formula weight	159190.9

*Water molecules are not included.