7BT5

Crystal structure of plasmodium LysRS complexing with an antitumor compound

7BT5 の概要

• エントリーDOI: 10.2210/pdb7bt5/pdb
• 分子名称: Lysine--tRNA ligase, LYSINE, N4-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: protein translation, lysyl-trna synthetase, ligase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121018.15

構造登録者

Zhou, J.,Wang, J.,Fang, P. (登録日: 2020-03-31, 公開日: 2020-09-30, 最終更新日: 2023-11-29)

• 主引用文献: Zhou, J.,Huang, Z.,Zheng, L.,Hei, Z.,Wang, Z.,Yu, B.,Jiang, L.,Wang, J.,Fang, P.; Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor.; Nucleic Acids Res., 48:11566-11576, 2020; PubMed: 33053158; DOI: 10.1093/nar/gkaa862

実験手法

X-RAY DIFFRACTION (2.493 Å)