7BPH
Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GN13
Summary for 7BPH
Entry DOI | 10.2210/pdb7bph/pdb |
Related PRD ID | PRD_002362 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, GN13, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (7 entities in total) |
Functional Keywords | g protein, gnas, adenylyl cyclase, active state, inhibitor, mrna display, rapid, cyclic peptide, gsin-1, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 46397.79 |
Authors | Hu, Q.,Dai, S.,Shokat, K.M. (deposition date: 2020-03-22, release date: 2021-03-31, Last modification date: 2023-11-29) |
Primary citation | Dai, S.A.,Hu, Q.,Gao, R.,Blythe, E.E.,Touhara, K.K.,Peacock, H.,Zhang, Z.,von Zastrow, M.,Suga, H.,Shokat, K.M. State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 2022 Cited by PubMed: 36170854DOI: 10.1016/j.cell.2022.09.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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