7BJ8

Structure of L1 with 2-Mercaptomethyl-thiazolidine D-syn-1b

Summary for 7BJ8

• Entry DOI: 10.2210/pdb7bj8/pdb
• Descriptor: Metallo-beta-lactamase L1, (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: antibiotic resistance, lactamase, zinc, inhibitor, antimicrobial protein
• Biological source: Stenotrophomonas maltophilia (Pseudomonas maltophilia)
• Total number of polymer chains: 1
• Total formula weight: 29496.94

Authors

Hinchliffe, P.,Spencer, J. (deposition date: 2021-01-14, release date: 2021-09-15, Last modification date: 2024-01-31)

• Primary citation: Hinchliffe, P.,Moreno, D.M.,Rossi, M.A.,Mojica, M.F.,Martinez, V.,Villamil, V.,Spellberg, B.,Drusano, G.L.,Banchio, C.,Mahler, G.,Bonomo, R.A.,Vila, A.J.,Spencer, J.; 2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-beta-Lactamase Classes by Maintaining a Conserved Binding Mode.; Acs Infect Dis., 7:2697-2706, 2021; PubMed: 34355567; DOI: 10.1021/acsinfecdis.1c00194

Experimental method

X-RAY DIFFRACTION (1.69 Å)