7BES

CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP

Summary for 7BES

Entry DOI	10.2210/pdb7bes/pdb
EMDB information	12158
Descriptor	Uridylate kinase, URIDINE-5'-DIPHOSPHATE, URIDINE 5'-TRIPHOSPHATE (3 entities in total)
Functional Keywords	nucleotide metabolism, ump kinase, allosteric regulation, antibacterial target, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	3
Total formula weight	91058.44
Authors	Bous, J.,Trapani, S.,Walter, P.,Bron, P.,Munier-Lehmann, H. (deposition date: 2020-12-24, release date: 2022-01-12, Last modification date: 2022-08-24)
Primary citation	Walter, P.,Mechaly, A.,Bous, J.,Haouz, A.,England, P.,Lai-Kee-Him, J.,Ancelin, A.,Hoos, S.,Baron, B.,Trapani, S.,Bron, P.,Labesse, G.,Munier-Lehmann, H. Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target. Febs J., 289:4869-4887, 2022 Cited by PubMed: 35152545 DOI: 10.1111/febs.16393 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.85 Å)

Structure validation