7BES
CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006225 | biological_process | UDP biosynthetic process |
| A | 0009041 | molecular_function | UMP/dUMP kinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0033862 | molecular_function | UMP kinase activity |
| A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006225 | biological_process | UDP biosynthetic process |
| B | 0009041 | molecular_function | UMP/dUMP kinase activity |
| B | 0016301 | molecular_function | kinase activity |
| B | 0033862 | molecular_function | UMP kinase activity |
| B | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006225 | biological_process | UDP biosynthetic process |
| C | 0009041 | molecular_function | UMP/dUMP kinase activity |
| C | 0016301 | molecular_function | kinase activity |
| C | 0033862 | molecular_function | UMP kinase activity |
| C | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| C | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue UDP A 301 |
| Chain | Residue |
| A | LYS36 |
| A | MET101 |
| A | GLY157 |
| A | MET158 |
| A | LEU160 |
| A | PHE163 |
| A | SER164 |
| A | THR165 |
| A | THR168 |
| A | GLY38 |
| A | GLY39 |
| A | GLY77 |
| A | GLY78 |
| A | PHE81 |
| A | ARG82 |
| A | GLY83 |
| A | ASP97 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue UDP B 301 |
| Chain | Residue |
| B | LYS36 |
| B | GLY38 |
| B | GLY39 |
| B | GLY76 |
| B | GLY77 |
| B | GLY78 |
| B | PHE81 |
| B | ARG82 |
| B | GLY83 |
| B | ASP97 |
| B | GLY100 |
| B | MET101 |
| B | GLY157 |
| B | MET158 |
| B | LEU160 |
| B | PHE163 |
| B | SER164 |
| B | THR165 |
| B | THR168 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue UTP B 302 |
| Chain | Residue |
| B | LEU138 |
| B | LEU140 |
| B | ARG141 |
| B | ARG144 |
| B | LYS148 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue UDP C 301 |
| Chain | Residue |
| C | LYS36 |
| C | GLY39 |
| C | GLY77 |
| C | GLY78 |
| C | PHE81 |
| C | ARG82 |
| C | GLY83 |
| C | ASP97 |
| C | GLY100 |
| C | GLY157 |
| C | MET158 |
| C | LEU160 |
| C | TYR162 |
| C | PHE163 |
| C | THR165 |
| C | THR168 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue UTP C 302 |
| Chain | Residue |
| A | LEU138 |
| A | LEU140 |
| A | ARG141 |
| A | ARG144 |
| A | LYS148 |
| C | ARG123 |
| C | GLY131 |
| C | ALA134 |
| C | GLU135 |
| C | PRO136 |
| C | ARG141 |
| C | ARG144 |
| C | HIS145 |
| C | LYS148 |
| C | ARG150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01220 |
| Chain | Residue | Details |
| A | LYS36 | |
| A | GLY77 | |
| A | GLY78 | |
| A | ARG82 | |
| A | ASP97 | |
| A | MET158 | |
| A | PHE191 | |
| A | ASP194 | |
| B | LYS36 | |
| B | GLY77 | |
| B | GLY78 | |
| B | ARG82 | |
| B | ASP97 | |
| B | MET158 | |
| B | PHE191 | |
| B | ASP194 | |
| C | LYS36 | |
| C | GLY77 | |
| C | GLY78 | |
| C | ARG82 | |
| C | ASP97 | |
| C | MET158 | |
| C | PHE191 | |
| C | ASP194 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | THR2 | |
| B | THR2 | |
| C | THR2 |
