7BES

CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0033862	molecular_function	UMP kinase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0033862	molecular_function	UMP kinase activity
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006225	biological_process	UDP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0033862	molecular_function	UMP kinase activity
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue UDP A 301

Chain	Residue
A	LYS36
A	MET101
A	GLY157
A	MET158
A	LEU160
A	PHE163
A	SER164
A	THR165
A	THR168
A	GLY38
A	GLY39
A	GLY77
A	GLY78
A	PHE81
A	ARG82
A	GLY83
A	ASP97

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site_id	AC2
Number of Residues	19
Details	binding site for residue UDP B 301

Chain	Residue
B	LYS36
B	GLY38
B	GLY39
B	GLY76
B	GLY77
B	GLY78
B	PHE81
B	ARG82
B	GLY83
B	ASP97
B	GLY100
B	MET101
B	GLY157
B	MET158
B	LEU160
B	PHE163
B	SER164
B	THR165
B	THR168

---

site_id	AC3
Number of Residues	5
Details	binding site for residue UTP B 302

Chain	Residue
B	LEU138
B	LEU140
B	ARG141
B	ARG144
B	LYS148

---

site_id	AC4
Number of Residues	16
Details	binding site for residue UDP C 301

Chain	Residue
C	LYS36
C	GLY39
C	GLY77
C	GLY78
C	PHE81
C	ARG82
C	GLY83
C	ASP97
C	GLY100
C	GLY157
C	MET158
C	LEU160
C	TYR162
C	PHE163
C	THR165
C	THR168

---

site_id	AC5
Number of Residues	15
Details	binding site for residue UTP C 302

Chain	Residue
A	LEU138
A	LEU140
A	ARG141
A	ARG144
A	LYS148
C	ARG123
C	GLY131
C	ALA134
C	GLU135
C	PRO136
C	ARG141
C	ARG144
C	HIS145
C	LYS148
C	ARG150

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01220","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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