7BES
CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005886 | cellular_component | plasma membrane |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006225 | biological_process | UDP biosynthetic process |
A | 0009041 | molecular_function | UMP/dUMP kinase activity |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0033862 | molecular_function | UMP kinase activity |
A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005886 | cellular_component | plasma membrane |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006225 | biological_process | UDP biosynthetic process |
B | 0009041 | molecular_function | UMP/dUMP kinase activity |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0033862 | molecular_function | UMP kinase activity |
B | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005886 | cellular_component | plasma membrane |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006225 | biological_process | UDP biosynthetic process |
C | 0009041 | molecular_function | UMP/dUMP kinase activity |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0033862 | molecular_function | UMP kinase activity |
C | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
C | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue UDP A 301 |
Chain | Residue |
A | LYS36 |
A | MET101 |
A | GLY157 |
A | MET158 |
A | LEU160 |
A | PHE163 |
A | SER164 |
A | THR165 |
A | THR168 |
A | GLY38 |
A | GLY39 |
A | GLY77 |
A | GLY78 |
A | PHE81 |
A | ARG82 |
A | GLY83 |
A | ASP97 |
site_id | AC2 |
Number of Residues | 19 |
Details | binding site for residue UDP B 301 |
Chain | Residue |
B | LYS36 |
B | GLY38 |
B | GLY39 |
B | GLY76 |
B | GLY77 |
B | GLY78 |
B | PHE81 |
B | ARG82 |
B | GLY83 |
B | ASP97 |
B | GLY100 |
B | MET101 |
B | GLY157 |
B | MET158 |
B | LEU160 |
B | PHE163 |
B | SER164 |
B | THR165 |
B | THR168 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue UTP B 302 |
Chain | Residue |
B | LEU138 |
B | LEU140 |
B | ARG141 |
B | ARG144 |
B | LYS148 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue UDP C 301 |
Chain | Residue |
C | LYS36 |
C | GLY39 |
C | GLY77 |
C | GLY78 |
C | PHE81 |
C | ARG82 |
C | GLY83 |
C | ASP97 |
C | GLY100 |
C | GLY157 |
C | MET158 |
C | LEU160 |
C | TYR162 |
C | PHE163 |
C | THR165 |
C | THR168 |
site_id | AC5 |
Number of Residues | 15 |
Details | binding site for residue UTP C 302 |
Chain | Residue |
A | LEU138 |
A | LEU140 |
A | ARG141 |
A | ARG144 |
A | LYS148 |
C | ARG123 |
C | GLY131 |
C | ALA134 |
C | GLU135 |
C | PRO136 |
C | ARG141 |
C | ARG144 |
C | HIS145 |
C | LYS148 |
C | ARG150 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01220 |
Chain | Residue | Details |
A | LYS36 | |
B | GLY77 | |
B | GLY78 | |
B | ARG82 | |
B | ASP97 | |
B | MET158 | |
B | PHE191 | |
B | ASP194 | |
C | LYS36 | |
C | GLY77 | |
C | GLY78 | |
A | GLY77 | |
C | ARG82 | |
C | ASP97 | |
C | MET158 | |
C | PHE191 | |
C | ASP194 | |
A | GLY78 | |
A | ARG82 | |
A | ASP97 | |
A | MET158 | |
A | PHE191 | |
A | ASP194 | |
B | LYS36 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
Chain | Residue | Details |
A | THR2 | |
B | THR2 | |
C | THR2 |